Esters are attached to the testosterone molecule by a process called hydrolysis. Esters are essentially a class of organic compounds that react with water to produce alcohols and organic or inorganic acids. This equates to a chain of carbon atoms that makes the molecule less soluble. The testosterone molecule can only become bioavailable when enzymes from the liver break down the carbon chains releasing the testosterone.
The longer the carbon chain, the longer this process takes. Through clinical experience, I have become a huge proponent of daily subcutaneous Testosterone Cypionate injections, not only to achieve stable male androgen levels, but also to mimic natural physiology. In some patients with high-normal Sex-Hormone Binding Globulin levels, it is possible to achieve stable levels with a less intensive injection frequency, however there is a reported qualitative difference in well-being with daily injections.
There is natural diurnal variation in testosterone levels throughout the day, with levels being at their highest in the morning as anabolic processes predominate at night. Irrespective of how stable your levels are, by the very nature of injecting a hormone, there will be a slight peak and so daily injections makes perfect sense. The similarity in ester length in both Testosterone Cypionate and Testosterone Enanthate, makes them essentially interchangeable.
However, the increased fluidity of the olive oil solvent in Testosterone Cypionate, alongside its low concentration of Benzoyl Alcohol preservative, makes Cypionate a preferable choice for subcutaneous injections. Testosterone Enanthate contains the carboxylic acid ester, enanthoic acid. It has a half-life of approximately days. According the British National Formulary, a single dose of mg Testosterone Enanthate should be injected every weeks 1. According to the manufacturer, a single injection of mg leads to an increase in total plasma testosterone between It was also noted that testosterone levels returned to baseline typically after 2 weeks, so the suggested 3-week injection frequency would be ineffective in rising baseline figures 2.
Steady-state mean serum levels of testosterone, bioavailable testosterone T , dihydrotestosterone DHT , and estradiol in thirty-three hypogonadal to year-old men given mg of intramuscular testosterone enanthate every 2 weeks. Error bars indicate standard deviations. Dashed lines denote upper and lower limits of normal range.
Adapted, with permission, from Dobs et al. The pharmacokinetic properties of Sustanon are not too dissimilar to that of Testosterone Enanthate. Levels then return to baseline after approximately 21 days, longer than Enanthate, presumably due to the longer half-life of the decanoate ester 4. Unfortunately, in practice, this is not the case. My personal belief is to take it from the start at very low doses and then increase when needed.
Some prefer to take nothing but the gear when on cycle. So this is why I choose. Week Adex starting. And the long esters sould help make the switch to Test E pretty smooth. All gear on hand except the adex, adex will arrive in 4 weeks, what tou guys think, start or wait? I took one 10mg tab with my 3 major meals. Breakfast, lunch, and supper. That worked out quite well for me. Water is fine to assist in swallowing.
Testosterone enanthate has the ability to improve aggression, libido, and muscle mass while promoting the better health. Testosterone enanthate is also associated with decreased visceral fat mass, decreased total cholesterol, and glycemic control besides regulating cognitive and physical energy and maintenance of muscle trophism.
Sustanon versus Testosterone Enanthate When it comes to comparing Sustanon and Testosterone Enanthate, the primary difference lies in the ester length. Sustanon , being a fairly long-estered combination of Testosterone, takes a bit longer to "kick in" but benefits from this anabolic compound can be achieved with less of frequent injections. Testosterone Enanthate, on the other hand, is required to be administered every week due to shorter esters though its effects are quicker than Sustanon.
Testosterone enanthate, when used for cycles of weeks, is an ideal steroid as it is easier for athletes to determine and manage testosterone levels. Though, this advantage may gets somewhat lost when the duration of the cycle is weeks as effects of the steroid would start showing up after weeks. Because of the mixed esters, Sustanon is a difficult steroid to deal with when it comes to efficient management of blood levels. However, Testosterone enanthate is believed to be more tolerable than Sustanon when it comes to estrogenic side-effect management.
This is due to the fact that testosterone blood levels tend to build at a slow pace with Testosterone enanthate use and this also means that side effects do not show up early. The choice between Sustanon and Testosterone Enanthate solely depends on expectations from steroid cycle and past experiences if any. Subscribe to our Underground Evo mailing list and get interesting news and updates directly to your inbox.
A noticeable difference between Testosterone Cypiontae and Enanthate is the carrier oil. Testosterone Enanthate is dissolved in sesame oil which is very viscous. One downside of having such a high viscosity is that preparation of the injection with Enanthate can be quite time-consuming, which does not lend well to long-term patient compliance and concordance.
I am becoming more and more of a proponent of subcutaneous testosterone injections. The subcutaneous route allows for slower absorption compared to the intramuscular route, which in turn leads to more stable levels, decreased aromatisation of testosterone to oestrogen and less possible negative side effects. The high viscosity of the sesame oil in Testosterone Enanthate means that the medication can cause lumps within the skin and subsequent irritation, which some of my patients report as being quite painful.
Testosterone Cypionate uses olive oil as its carrier. Another consideration was that Testosterone Enanthate contains the preservative Chlorobutinol, which is a known irritant at high concentrations.
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