Which diuretics cause hypercalcemia

Older women were most at risk for PHP, and surgery was the usual treatment, he said at the joint meeting of the International Congress of Endocrinology and the Endocrine Society. In all, the team reviewed patients diagnosed with thiazide-associated hypercalcemia between and The findings suggest that "primary hyperparathyroidism is common in patients who develop hypercalcemia while taking thiazide diuretics," the investigators said. Compared with the overall patient population of , those who were diagnosed with PHP had a slightly higher maximum serum calcium while on thiazides mean Serum calcium was normal in both groups before thiazide treatment median 9.

The overall incidence of thiazide associated hypercalcemia was 17 cases per , person-years. The highest rate was The incidence started climbing in the mids and peaked in at In , the incidence was about 20 cases per , person-years. Skip to main content. Conference Coverage. Thiazide diuretics commonly unmask primary hyperparathyroidism.

Because hypercalcemia in these patients was not evaluated and managed in systematic fashion, the frequencies of various outcomes are only approximations. However, two take-home points are evident. First, underlying primary hyperparathyroidism is present in a fairly large proportion of patients with thiazide-associated hypercalcemia. And second, because the hypercalcemia tends to be mild and nonprogressive, we can reasonably continue thiazide therapy if compelling reasons exist to do so e.

Griebeler ML et al. Thiazide-associated hypercalcemia: Incidence and association with primary hyperparathyroidism over two decades. J Clin Endocrinol Metab Mar; J Clin Endocrinol Metab Mar Primary hyperparathyroidism is often, but not invariably, present in these patients. Comment Because hypercalcemia in these patients was not evaluated and managed in systematic fashion, the frequencies of various outcomes are only approximations.

Brett, MD, at time of publication Nothing to disclose. Citation s : Griebeler ML et al. October 18, New York. Pulmonary Disease. Bethesda, Maryland. North Carolina.